Neurog2 Drives Cell Cycle Exit of Neuronal Precursors by Specifically Repressing a 1 Subset of Cyclins Acting at the G1 and S Phases of the Cell Cycle 2 3
نویسندگان
چکیده
Marine Lacomme, Laurence Liaubet, Fabienne Pituello et Sophie Bel-Vialar 4 Centre de Biologie du Développement, CNRS UMR5547, Toulouse, France 31062 Toulouse, 5 Laboratoire de Génétique Cellulaire, INRA UMR444, Castanet Tolosan France 6 7 8 Corresponding author: Sophie Bel-Vialar [email protected] 9 Co-Corresponding author: Fabienne Pituello [email protected] 10 11 Running title: NEUROG2 represses G1/S cyclins in the neural tube 12
منابع مشابه
NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.
Proneural NEUROG2 (neurogenin 2 [Ngn2]) is essential for neuronal commitment, cell cycle withdrawal, and neuronal differentiation. Although NEUROG2's influence on neuronal commitment and differentiation is beginning to be clarified, its role in cell cycle withdrawal remains unknown. We therefore set out to investigate the molecular mechanisms by which NEUROG2 induces cell cycle arrest during sp...
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